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Usual Geriatric Dose for Depression:

Immediate-release tablets, orally disintegrating tablets, oral concentrate:
Initial dose: 0.25 mg orally 2 to 3 times a day in elderly or debilitated patients
This dose may be gradually increased if needed and tolerated.

Because of increased sensitivity to benzodiazepines in elderly patients, alprazolam at daily doses greater than 2 mg meets the Beers criteria as a medication that is potentially inappropriate for use in older adults. Smaller doses may be effective as well as safer but, total daily doses should rarely exceed suggested maximums.

Usual Geriatric Dose for Panic Disorder:

Immediate-release tablets, orally disintegrating tablets:
Initial dose: 0.25 mg orally 2 to 3 times a day in elderly or debilitated patients
This dose may be gradually increased if needed and tolerated.

Extended-release tablets:
Initial dose: 0.5 mg once a day preferably in the morning
This dose may be gradually increased if needed and tolerated.

Because of increased sensitivity to benzodiazepines in elderly patients, alprazolam at daily doses greater than 2 mg meets the Beers criteria as a medication that is potentially inappropriate for use in older adults. Smaller doses may be effective as well as safer. So, the total daily doses should rarely exceed suggested maximums.


Finally, taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • cimetidine;
  • digoxin;
  • fluvoxamine;
  • nefazodone;
  • ritonavir or other medicines to treat HIV or AIDS; or
  • antifungal medicine – fluconazole, voriconazole.

This list is not complete. Other drugs may interact with alprazolam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

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What is Xanax and when is it used?

This medicine contains alprazolam, a substance from the group of benzodiazepines, as the active ingredient. Xanax has an anxiolytic, relaxing, and calming effect. It is used to treat anxiety, tension and panic disorders.


What precautions should be taken?
Simultaneous consumption of alcohol or certain other drugs can increase the effect of drugs containing benzodiazepines such as Xanax.

When should Xanax  not be used?
Xanax must not be take in the event of hypersensitivity to benzodiazepines or any other component of the preparation, as well as

Pathological muscle weakness (myasthenia gravis), severe impairment of respiratory function, respiratory failure during sleep (sleep apnea syndrome) and severe impairment of liver function.

This medicine must not be take with certain anti-fungal agents or agents used to treat AIDS (so-call protease inhibitors).

When should caution be advised when taking Xanax?

This medicinal product can impair the ability to react, drive, and use tools or machines!

Dependency risk

As with all benzodiazepine-containing preparations, taking Xanax can lead to dependence. This can occur especially with uninterrupted use over a long period (in certain cases after a few weeks) and results in withdrawal symptoms after abrupt discontinuation of the drug. Restlessness, anxiety, insomnia, poor concentration, headaches, and sweating can then occur. These dependency effects may become less after two to three weeks.

To keep the risk of developing addiction as low as possible, please note the following:

  • Only take Xanax as directed by your doctor.
  • Tell your doctor if you want to stop taking the medicine.
  • Your doctor will periodically decide whether treatment needs to be continue.
  • Long-term use (usually more than four weeks) may only take place under careful medical supervision.
  • The simultaneous use of Xanax and opioids can lead to a strong depression of certain brain functions with severe breathing disorders up to unconsciousness and death and must therefore be avoid.

This medicine must be dosed carefully in patients with impaired kidney or liver function.

In patients suffering from depression, treatment with Xanax can lead to certain mild to severe pathological symptoms (so-called manias).

The effect of this medication is increase by the simultaneous use of sedatives, strong pain medicines and other drugs that affect the CNS, as well as  drinks contain alcohol.

Certain antibiotics, anti-high blood pressure medicines, anti-depression medicines and some other medicines can affect and increase the way This tablet works. This tablet can also affect the way some other medicines work (e.g. lithium and digoxin). It is therefore imperative that you inform your doctor that you are taking other medicines.

This medicine should be dose carefully in elderly patients because these people are more sensitive to Xanax than younger patients.

Drug or drug abuse is a know risk with Xanax use. Xanax may only be give to patients who are prone to drug abuse, as well as alcohol addicts and drug users, in exceptional situations and under strict medical supervision. Patients receiving Xanax should also be monitor appropriately during treatment.

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Xanax tablets.

The use of Xanax in children and adolescents under 18 years of age has not been studied.

Can Xanax be used during pregnancy or breastfeeding?

This tablet should not be use during pregnancy, especially during the first three months, and while breastfeeding. If you are pregnant or want to become pregnant, it is imperative that you consult your doctor.

If use late in pregnancy or during childbirth, side effects may occur in the newborn. Newborns whose mothers have frequently taken benzodiazepine-containing preparations during pregnancy may develop addiction and therefore show withdrawal symptoms.

If it is necessary to take This tablet while breast-feeding, you must stop breast-feeding.

How do you use Xanax?
The doctor will determine the dosage that is suitable for you, as well as the duration of treatment and when to take the tablets.

Usual dosage instructions
The usual dose is 0.5 to 1.5 mg daily in divided doses. Depending on the patient’s response, up to 4 mg daily, and in isolated cases up to 6 mg, may be necessary. The tablets are swallow whole with some liquid.

This tablet is oblong and has three break lines. To divide, the tablet is place on a hard surface with the embossing facing up and press onto the center of the tablet with the thumb. The two halves can be divide further in the same way. This results in 4 parts of 0.5 mg each.

Affect disorder (hypomania, mania), illusion (hallucination), anger, aggression, hostility, pathological restlessness, absurd thinking, increased psychomotor activity, drug or drug abuse, drug withdrawal syndrome, abnormal involuntary muscle tension, gastrointestinal complaints, inflammation of the liver (hepatitis) Liver function, jaundice, bladder weakness, urinary retention, skin inflammation, angioedema (fluid accumulation in the skin and / or mucous membrane), increased sensitivity of the skin to light (photosensitivity), sexual dysfunction, altered sexual sensation, irregular menstrual period, increased intraocular pressure, fluid accumulation e.g. in the arms or in the Legs (peripheral edema), hypersensitivity reactions (such as hives, swelling in the throat and larynx).

If you get any side effects, talk to your doctor, pharmacist or health care professional. This also applies in particular to side effects not listed in this leaflet.

What should also be note?
The drug may only be use up to the date marked “EXP” on the pack.

Store protected from light and dry at room temperature (15-25 ° C) and out of the reach of children.

What is in Xanax / Retard?
1 tablet of 0.25 mg contains 0.25 mg alprazolam. It is white and oval and is emboss with “Upjohn 29” on one side and a groove on the other.

1 tablet of 0.5 mg contains 0.5 mg alprazolam. It is pink and oval and is emboss with “Upjohn 55” on one side and a groove on the other.

1 tablet of 1 mg contains 1 mg alprazolam. It is purple and oval and is emboss with “Upjohn 90” on one side and a groove on the other.

1 tablet of 2 mg contains 2 mg of alprazolam. It is white and oblong and is emboss with “U94” on one side and three break lines on each side.

The tablets also contain the following additives:

Lactose, microcrystalline cellulose, docusate sodium, highly dispersed silicon dioxide, corn starch, magnesium stearate, coloring agents: erythrosine (E127; tablets of 0.5 mg and 1 mg), indigotine (E132; tablets of 1 mg); Preservative: Sodium Benzoate (E211).

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