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OxyContin is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
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OxyContin is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.Limitations of Use
- Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve OxyContin for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
- OxyContin is not indicated as an as-needed (prn) analgesic.
QUALITATIVE AND QUANTITATIVE COMPOSITION OF OXYCODONE HYDROCHLORIDE
5 mg tablet contains 4.5 mg of oxycodone as 5 mg of oxycodone hydrochloride
10 mg tablet contains 9.0 mg of oxycodone as 10 mg of oxycodone hydrochloride
15 mg tablet contains 13.5 mg of oxycodone as 15 mg of oxycodone hydrochloride
20 mg tablet contains 18.0 mg of oxycodone as 20 mg of oxycodone hydrochloride
30 mg tablet contains 27 mg of oxycodone as 30 mg of oxycodone hydrochloride
40 mg tablet contains 36.0 mg of oxycodone as 40 mg of oxycodone hydrochloride
60 mg tablet contains 54 mg of oxycodone as 60 mg of oxycodone hydrochloride
80 mg tablet contains 72.0 mg of oxycodone as 80 mg of oxycodone hydrochloride
120 mg tablet contains 108 mg of oxycodone as 120 mg of oxycodone hydrochloride
Prolonged release round, convex tablet.
The 5 mg tablets are light blue, marked OC (Oxycodone 5mg) on one side and 5 on the other.
The 10 mg tablets are white, marked OC (Oxycodone 10mg) on one side and 10 on the other.
The 15 mg tablets are grey, marked OC (Oxycodone 15mg) on one side and 15 on the other.
The 20 mg tablets are pink, marked OC (Oxycodone 20mg) on one side and 20 on the other.
The 30 mg tablets are brown, marked OC (Oxycodone 30mg) on one side and 30 on the other.
The 40 mg tablets are yellow, marked OC (Oxycodone 40mg) on one side and 40 on the other.
The 60 mg tablets are red, marked OC (Oxycodone 60mg) on one side and 60 on the other.
The 80 mg tablets are green, marked OC (Oxycodone 80mg) on one side and 80 on the other.
The 120 mg tablets are purple, marked OC (Oxycodone 120mg) on one side and 120 on the other.
FERTILITY, PREGNANCY AND LACTATION
OxyContin tablets are not recommended for use in pregnancy nor during labour.
There are limited data from the use of oxycodone in pregnant women. Infants born to mothers who have received opioids during the last 3 to 4 weeks before giving birth should be monitored for respiratory depression. Withdrawal symptoms may be observed in the newborn of mothers undergoing treatment with oxycodone.
Oxycodone may be secreted in breast milk and may cause respiratory depression in the newborn. OxyContin tablets should, therefore, not be used in breast-feeding mothers.
CONTRAINDICATIONSOxyContin is contraindicated in patients with:
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
- Hypersensitivity (e.g., anaphylaxis)
WARNINGS AND PRECAUTIONS Buy Oxycodone – Oxycodone
- OxyContin contains oxycodone, a Schedule II controlled substance. OxyContin exposes users to the risks of opioid addiction, abuse, and misuse.. Advise pregnant women using opioids for a prolonged period of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.
- The use of OxyContin in patients with acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment is contraindicated. OxyContin-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of OxyContin.Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients.Monitor such patients closely, particularly when initiating and titrating OxyContin and when OxyContin is given concomitantly with other drugs that depress respiration. Alternatively, consider the use of non-opioid analgesics in these patients.
- Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. If adrenal insufficiency is suspected, confirm the diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers.
- OxyContin is contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus. OxyContin may cause spasm of the sphincter of Oddi. Opioids may cause increases in the serum amylase. Monitor patients with biliary tract disease, including acute pancreatitis.
- The oxycodone in OxyContin may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during OxyContin therapy.
- Avoid the use of mixed agonist/antagonist (e.g., pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including OxyContin. In these patients, mixed agonist/antagonist and partial agonist analgesics may reduce the analgesic effect and/or may precipitate withdrawal symptoms. When discontinuing OxyContin, gradually taper the dosage. Do not abruptly discontinue OxyContin.
- OxyContin may impair the mental or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery. Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of OxyContin and know how they will react to the medication.
- Not every urine drug test for “opioids” or “opiates” detects reliably, especially those designed for in-office use. Further, many laboratories will report urine drug concentrations below a specified “cut-off” value as “negative.” Therefore, if urine testing for considered in the clinical management of an individual patient, ensure that the sensitivity and specificity of the assay is appropriate, and consider the limitations of the testing used when interpreting results.
ADVERSE REACTIONS Buy Oxycodone Online
- OxyContin may increase the risk of serious adverse reactions such as those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock. The most common adverse reactions (>5%) reported by adult patients in clinical trials comparing OxyContin with placebo are constipation, nausea, somnolence, dizziness, pruritus, vomiting, headache, dry mouth, asthenia, and sweating.
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